Pii: S0730-725x(00)00209-5

This note describes the implementation of a three-dimensional (3D) registration algorithm, generalizing a previous 2D version [Alexander, Int J Imaging Systems and Technology 1999;10:242–57]. The algorithm solves an integrated form of linearized image matching equation over a set of 3D rectangular sub-volumes (‘patches’) in the image domain. This integrated form avoids numerical instabilities due to differentiation of a noisy image over a lattice, and in addition renders the algorithm robustness to noise. Registration is implemented by first convolving the unregistered images with a set of computationally fast [O(N)] filters, providing four bandpass images for each input image, and integrating the image matching equation over the given patch. Each filter and each patch together provide an independent set of constraints on the displacement field derived by solving a set of linear regression equations. Furthermore, the filters are implemented at a variety of spatial scales, enabling registration parameters at one scale to be used as an input approximation for deriving refined values of those parameters at a finer scale of resolution. This hierarchical procedure is necessary to avoid false matches occurring. Both downsampled and oversampled (undecimating) filtering is implemented. Although the former is computationally fast, it lacks the translation invariance of the latter. Oversampling is required for accurate interpolation that is used in intermediate stages of the algorithm to reconstruct the partially registered from the unregistered image. However, downsampling is useful, and computationally efficient, for preliminary stages of registration when large mismatches are present. The 3D registration algorithm was implemented using a 12-parameter affine model for the displacement: u(x) 5 Ax 1 b. Linear interpolation was used throughout. Accuracy and timing results for registering various multislice images, obtained by scanning a melon and human volunteers in various stationary positions, is described. The algorithm may be generalized to more general models of the displacement field, and is also well suited to parallel processing. © 2000 Elsevier Science Inc. All rights reserved.